abstract background: asterocytoma is the most common primary human brain tumor which has the most lethal hazard among tumors in human central nervous system. heat shock proteins play an active role in cancer cells pathways through their effects on tumor cell proliferation, tumor differentiation, malignancy, metastasis, and cell death. hsp 70 is a 70 kd protein that its expression change has bee...

to better understand seed dormancy breaking of bread wheat (triticum aestivum l.rl4137), we examined protein synthesis in dormant and after-ripened seeds.we used six treatments including dormant seed, dormant seed that were subjected to gibberllic acid (ga3) for 10 hours, dormant seed with one, three and six weeks of after-ripening and finally six weeks after-ripened seed subjected to abscisc a...

Triterpenoids are implicated in the chemoprevention of various cancers. Current challenge is to define the molecular mechanism underlying the chemopreventive activity of triterpenoids. This study was designed to characterize the intracellular proteins regulated by astragaloside IV, the major active triterpenoid in Radix Astragali. Upon the treatment with astragaloside IV, human hepatocellular c...

background: viscerotropic leishmaniasis caused by leishmania tropica poses a significant prob­lem in the diagnosis and treatment management. since differential gene expression is more im­portant in outcome of the infection, we employed proteomic approach to identify potential pro­teins involved in visceralization of l. tropica . methods: the proteomes profiling of l. tropica isolated from cutan...

Wilson's disease (WD) is characterized by excessive accumulation of intracellular copper in liver and extrahepatic tissues, leading to significant oxidative stress and tissue damage. To date, several diagnostic biomarkers for WD such as serum ceruloplasmin, serum or urine copper levels and copper content in liver have been identified. However, these biomarkers may not be convincing for the diag...

results results of the current study showed that the minimum inhibitory concentration value of cinnamaldehyde against m. tuberculosis was 200 µg/ml. moreover, rt-pcr data showed that a total of 25 genes were regulated by the cinnamaldehyde. of these, 12 genes were up-regulated, and 13 genes were down-regulated. conclusions cinnamaldehyde is a pattern to expand the new anti-tb drugs, because the...

background: glucantime ® is the first- line drug for the treatment of all forms of leishmaniasis. unfortunately, the prevalence of parasites becoming resistant to glucantime ® is increasing in several parts of the world including iran. as protein is the most important target for drugs in response to a variety of signals including drugs so, it seems expression protein patterns in sensitive and r...