objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...

conclusions some results of the correlation coefficients are not the same with visualization. the reason may be due to the small number of data. materials and methods in the foundation-application study, we constructed two-way gene networks using nonparametric methods, such as spearman’s rank correlation coefficient and blomqvist’s measure, and compared them with pearson’s correlation coefficie...

background: rna interference (rnai) is a phenomenon uses double-stranded rna (dsrna) to specifically inhibit gene expression. the non-specific silencing caused by interferon response to dsrna in mammalian cells limits the potential of utilizing rnai to study gene function. duplexes of 21-nucleotide short interfering dsrna (sirna) inhibit gene expression by rnai. in some organisms, sirna can als...

Introduction: The radiation induced bystander effect (BSE) is the induction of biological changes in unexposed cells, by signals transmitted from bystander cells that cause the spread of radiation toxicity to adjacent or far tissues. In addition, reactive oxygen species (ROS) and reactive nitrogen species (RNS) such as cytokines are involved in mediating mechanisms in bystande...

conclusions this study indicates that satureja khuzestaniea essence has inhibitory effects on the gene expression of antibiotic resistance in bla-oxa-23 that has a high mic. given that this essence has a good inhibitory effect on gene expression in mdr acinetobacter baumannii and bla-oxa-23, the results indicate that it could be used as a natural way to prevent the growth of acinetobacter bauma...

ischemia-reperfusion injury is the tissue damage happened when blood supply returns to the tissue after a period of ischemia or shortage of oxygen. this brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. the aim of this study is investigating the effect of hydroalcoholic extract of  cyperus rotundus l. on the expression of the bcl-x1 an...