نتایج جستجو برای: colorectal cancer cell line
تعداد نتایج: 2622543 فیلتر نتایج به سال:
Cross-Resistance of Acquired Radioresistant Colorectal Cancer Cell Line to gefitinib and regorafenib
Background: Usually, chemoradiotherapy can be used for the treatment of locally advanced colorectal cancer (CRC) before surgery. On the other hand, some studies have shown that fractional radiation of tumor cells leads to chemoresistance. The aim of this study was to evaluate the chemoresistance of radioresistant sub-line (RR sub-line).Methods: This study was done in Hamadan University of...
Despite recent advances in understanding colorectal tumour biology, there is still a need to improve the 5-year survival rate of patients with colorectal cancer as approximately 40% of patients presenting with advanced disease will remain resistant to therapy. One of the major contributing factors in resistance to therapy is the failure of colorectal tumour cells to undergo apoptosis. Hence the...
objective(s): ten-eleven translocation (tet) family members have been shown to be involved in the development of many tumors. however, the biological role of the tet family and its mechanism of action in colorectal carcinogenesis and progression remain poorly understood. materials and methods:we measured the expression levels of tet family members in colorectal cancer (crc) specimens, in the co...
Background: Colorectal cancer (CRC) is attributed as one of the most common malignancies worldwide. CD133 molecule, as a pentaspan transmembrane glycoprotein, confers stem cell-related characteristics, including self-renewal and multi-directional differentiation capability. CD133 plays important roles in the progression of CRC by conferring apoptotic resistance and migration ab...
colon cancer is cancer of the large intestine (colon), the lower part of digestive system and the third most common cancer in men and the second most common cancer in women worldwide. genetic background is thought to play a role in modulating individual risk to this cancer. many studies support an association for insulin pathway gene polymorphisms and the regulation of tumor cell biology in c...
Background: Colorectal cancer is one of the main causes of cancer death and the third most common malignant cancer worldwide. FGF14 is a member of the large family of fibroblast growth factors. These factors control a wide range of biological functions, including cell proliferation, survival, migration and differentiation that disturbing their expression can lead to cancer. The purpose of this ...
Anti-helmintic drugs mebendazole and albendazole are commonly used to treat a variety of parasitic infections. They have recently shown some promising results in pre-clinical vitro vivo anti-cancer studies. We compare their efficacy breast colon cancer cell lines as well non-cancerous cells elucidate mechanism action. The were screened for cytotoxicity MDA-MB-231, MCF-7 (breast cancer), HT-29 (...
Background & Aim: Despite the advances in treatment of colorectal adenocarcinoma patients continue to have low survival. Citric acid is considered as a physiological inhibitor of enzymes involved in glycolysis pathway to remove cancer cells. The p53 and p21 gene products are involved in cell removal due to their pro-apoptotic properties. In this study, the effect of citric acid on p53 and p21 g...
BACKGROUND Liver metastasis is the most common cause of death in patients with colorectal cancer. Despite extensive research into the biology of cancer progression, the molecular mechanisms that drive colorectal cancer metastasis are not well characterized. METHODS HT29 LM1, HT29 LM2, HT29 LM3 cell lines were derived from the human colorectal cancer cell line HT29 following multiple rounds of...
Colorectal cancer is the third most common cancer and is associated with significant morbidity and mortality. Epidemiological and animal studies indicate that regular acetylsalicylic acid (aspirin) intake is associated with a reduction in the incidence of colorectal cancer. Acetylsalicylic acid (ASA) has also been shown to inhibit colorectal cancer cell proliferation in vitro. The molecular bas...
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