We describe an efficient one-step synthesis of pyrrolo[3,4-c]quinolinedione derivatives using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and β-ketoamides. It is the first direct conversion of isatins to pyrrolo[3,4-c]quinolinedione derivatives via C-N bond cleavage and isatin ring expansion. Furthermore, this reaction provides a one-step synthetic route for the prod...

An objective definition of what a code clone is currently eludes the field. A small study was performed at an international workshop to elicit judgments and discussions from world experts regarding what characteristics define a code clone. Less than half of the clone candidates judged had 80% agreement amongst the judges. Judges appeared to differ primarily in their criteria for judgment rather...

factor (BDNF) and of its high-affinity receptor TrkB have previously been described in the avian embryo. During early embryonic development, BDNF mRNA expression was identified by reverse transcriptase/polymerase chain reaction (RT-PCR) beginning at stage 1 (3–4 h of embryo incubation), while trkB expression was not detected until the eight-somite stage (29 h) (Baig and Khan, 1996). These obser...

Two trials were conducted to study the effect of multi-steps phase-feeding (PF) program on growth performance of broiler chickens from 1 to 24 and 1 to 39 d of age. The control group was the nutrient recommendation of Aviagen (2019) with a three-step PF program (1-10, 11-24 and 25-39 d of age). In the first trial, the control group was compared with an eight-step PF program (PF8), and in the se...

The continuous growth in global population and the ongoing development of countries such as China and India have contributed to a rapid increase in worldwide energy demand. Fossil fuels such as oil and gas are finite resources, and their current rate of consumption cannot be sustained. This, coupled with fossil fuels' role as pollutants and their contribution to global warming, has led to incre...