Background: Rabies virus (RABV) is a deadly neurotropic virus that causes the disease of rabies in humans and animals. L protein is one of the large structural protein of rabies virus, which displays multiple enzymatic activities, and is required for viral transcription and replication. Objectives: A truncated L protein of Rabies virus is being cloned, expressed and purified to produce relevant...

Salmonella bacteria causes a wide variety of disease and disease syndrome in different animals, birds including human beings and remains as a serious problem with public health significance throughout the world. A suitable vaccine or suitable immunogen detection system is not yet still available. However, it is interesting to characterize of a common immunodominant surface protein from a wide v...

Phosphorylation is a posttranslational modification of proteins that regulates many biological functions, such as development, morphogenesis, gene expression, metabolism and neuronal activity. Dysregulation phosphorylation causes diseases including cancer Alzheimer’s disease. Then, lot research has been performed to reveal the molecular mechanism phosphorylation; identification site(s), protein...

diphtheria is a fatal disease caused by exotoxin of corynebacterium     diphtheria .  this toxin consists of   two chains, catalytic chain (a) and binding (b) chain. by binding chain (b),   the toxin binds to its receptor on numerous body cells such as myocardial,   kidney and peripheral nerve cells. after entering, catalytic chain (a)   inhibits protein synthesis and finally can cause cell dea...

Background: Xanthomonas citri subsp. citri (Xcc), the causative agent of bacterial citrus canker, has affected citriculture worldwide. Varieties of means have been used to minimize its devastating effects, but no attention has been given to bacteriocins. Objectives: Here and for the first time, we report the isolation and characterization of two novel bacteriocins. Materials and Methods: Secret...

Malaria is still an essential epidemiological disease worldwide, including in Indonesia. Several approaches are performed to control the disease, as well vaccine development. The Cysteine-rich interdomain region α of Plasmodium falciparum erythrocyte membrane protein 1 (CIDRα-PfEMP1) a pivotal domain malaria pathogenesis make it candidate. development using recombinant technology. Recombinant p...

background: rh (rhesus) is a highly complex blood group system in man deeply rooted in transfusion medicine. isolation of rhd from cord blod, cloning and expression of recombinant rhd antigen in bacterial expression system was the aim of this study. methods: total rnas were extracted from cord blood (o + ).  the quality of rna was determined by electrophoresis. in or­der to obtain coding sequen...