OBJECTIVE Impairment of spermatogenesis has been identified as an inevitable side effect of cancer treatment. Although estrogen treatment stimulates spermatogenic recovery from the impaired spermatogenesis by suppressing the intra-testicular testosterone (ITT) level, side effects of estrogen are still major impediments to its clinical application in humans. Soybeans are rich in genistein, which...

Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. In this article we propose new individualized busulfan dosing regimens, in order to increase safety and efficacy during busulfan therapy especially in very small children. Busulfan has a very narrow therapeutic range with higher AUC values causing a high risk of sinuosoidal obstruction syndrome...

Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by impaired phagocytic function. Hematopoietic stem cell transplantation (HSCT) is a definitive cure for CGD; however, the use of HSCT is limited because of associated problems, including transplantation-related mortality and engraftment failure. We report a case of a patient with CGD who underwent successful HSCT ...

An understanding of the number and contribution of individual pluripotent hematopoietic stem cells (HSCs) to the formation of blood lineages has important clinical implications for gene therapy and stem cell transplantation. We have been able to efficiently mark rhesus macaque long-term repopulating stem and progenitor cells with retroviral vectors, and track their in vivo contributions to hema...

BACKGROUND Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis and represent a crucial resource for male fertility restoration. It has not been well documented, however, whether the recovery of SSC population size after cytotoxic damage associates with the kinetics of male fertility restoration. We addressed this issue using the mouse as a model. METHODS Following single in...

Human hematopoietic stem cell (HSC) xenotransplantation in NOD/SCID mice requires recipient conditioning, classically achieved by sublethal irradiation. Pretreatment with immunosuppressive and alkylating agents has been reported, but has not been rigorously tested against standard irradiation protocols. Here, we report that treatment of mice with a single dose (35 mg/kg) of Busilvex, an injecta...

background: in traditional medicine zingiber officinale used to regulate female menstural cycle and treat male infertility. recent studies have suggested the possible role of ginger extract in improving the testicular damage of busulfan. objective: the aim of this study was to evaluate the effects of zingiber officinale on the sperm parameters, testosterone level and the volume of the testes an...

Objective: Busulfan(Bus) is a chemotherapy drug that is widely used for cancer treatment. The protective effect of CoQ10 evaluated on testis and sperm parameters after busulfan treatment. Design: Experimental Study Animals: Thirty tow adult male Wistar rats Procedures: In this experimental study 32 adult male Wistar rats have randomly divided into four groups: Control group ...

Background: In the past 2 decades, the survival rates for many of the malignancies that affectyoung women have significantly improved. For many of these malignancies, survival rates exceed 80-90%. Therefore, the remote effects of cancer treatment have recently gained worldwide interest, andthe protection against iatrogenic infertility caused by chemotherapy assumes high priority. Busulfan is a ...