A generic Mediator architecture for distributed task planning and coordination has been developed using multi-agent paradigms. In this approach, agents function autonomously as independent computing processes, and dynamic virtual clusters coordinate the agent’s activities and decision making. This coordination involves dynamically created coordination agents and resource agents concurrently. Th...

A combination of crystallography, biochemistry, and gene expression analysis identifies the coactivator subcomplex Med8C/18/20 as a functionally distinct submodule of the Mediator head module. Med8C forms a conserved alpha-helix that tethers Med18/20 to the Mediator. Deletion of Med8C in vivo results in dissociation of Med18/20 from Mediator and in loss of transcription activity of extracts. De...

This paper describes a technique for creating mediators— information system components that operate among distributed applications and distributed databases. The databases are distributed logically and physically, typically residing on different platforms and having different semantics. A mediator automates the process of merging widely differing databases into a seamless, unified whole to be p...

introduction: this study aims to explain the depression level based on life style through the mediation of social health and quality of life. statistical population was all persons over 18 years of ahwaz random sampling stage sample size were selected 383 people. method: research data in this study were collected by using a health promoting lifestyle questionnaire walker and plyrky, keynesian p...

The research is based on the designing of Clinical Temporal Mediator for medical domain. The Clinical Temporal Mediator incorporates the concept of artificial intelligence for performing temporal reasoning tasks. The designing of reasoning system involves the implementation of various mathematical models of insulin-glucose metabolism. The reasoning system consists of three subsystems: Nuti-Diet...

Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase II. Multiple subunits of the complex show specificity in relaying information from signals and transcription factors to the RNA polymerase II machinery, thus enabling control of the expression of specific genes. Recent studies have also provided novel mechanistic insights into the roles of Mediator in e...