Insulin resistance or insulin deficiency can cause diabetes, which has a high level of glucose in the blood (American Diabetes Association 2014). It's one most pressing issues modern public health. Around 366 million individuals had diabetes 2011, according to "International Federation" (IDF). This figure is expected rise 552 by end 2030. The average score semantic measure and Pearson correlati...

Insulin resistance is a condition in which insulin signaling and action are impaired in insulin sensitive tissues and results in hyperglycemia, hyperlipidemia and type 2 diabetes mellitus. Our previous studies have shown that rosa damascena has antihyperglycemic effects on diabetic and normal rats. Therefore, we conducted a study to evaluate the effect of this medicinal plant on insulin sensiti...

Objective(s):The purpose of this study was to investigate the effects of Noggin on high glucose-induced apoptosis and insulin secretion in pancreatic beta cells. Materials and Methods: Different concentrations of glucose were used to examine their effects on INS-1 rat beta cells in vitro. When specific siRNA targeting Noggin and recombinant Noggin were added, apoptosis and insulin secretion wer...

Type 2 Diabetes Mellitus (T2D) is the most common metabolic disease demonstrating itself by hyper- glycemia, due to impaired insulin secretion or action. Recently, Whole-Genome Association studies have revealed the role of several new genes responsible for T2D. One of the most studied genes is SLC30A8 (Zn-T8) which is exclusively expressed in pancreatic ?-cells and participates in insulin stora...

Objective: Laboratory studies on diabetic rats have shown that diabetic rats have a lower beta cell mass than healthy rats. On the other hand, over the years, with tremendous advances in genetic science, many studies have been done on the expression of genes and its effective factors, such as physical activity. One of these genes is AKT / PKB. Due to the association between the expression of th...

Objective(s): The aim of this study was to investigate the effect of vitamin D on glucose metabolism, as well as the expression of five key genes involved in the development of diabetes complications in liver tissue of diabetic rats. Materials and Methods: Twenty-four male Sprague–Dawley rats were randomly divided into three groups (8 ra...

Background: Metformin is an insulin sensitizing drug, which is co-administered with Clominophene citrate or gonadotropins in most cases of polycystic ovary syndrome (PCOS), to improve ovulation. STK11 gene is necessary for action of metformin. Therefore the study of STK11 polymorphisms is important as pharmacogenetics aspects of metformin. The aim of our study was to investigate polymorphism of...