In this study the role of CA1 region of dorsal hippocamus an amygdala kindling rate was investigated by bilateral microinjection of lidocaine into hippocampus.28 rats were divided into four groups.in group I:animals were implanted only with a tripolar electrode into the amygdala but in groups 2-4,two guide cannulaae were also implanted into  the CA1 region of the dorsale hippocampus.two monopol...

Dopamine is monoamine neurotransmitter. Dopamine is produced in the dopaminergic neurons in the ventral tegmental area of the substantia nigra, midbrain and the arcuate nucleus of the hypothalamus. In the periphery, dopamine is found in the kidney where it functions to produce renal vasodilation, diuresis, and natriuresis. Dopamine neurons are more widely distributed than those of other monamin...

His research area includes the mechanism by which prostanoids, small molecules generated by enzymes called cyclooxygenases, are involved in pathological processes. Dr. Boutaud demonstrated for the first time that γ-ketoaldehydes are generated by the cyclooxy-genases during their normal catalytic cycle [1, 2]. Dr. Boutaud further led the effort in characterizing the structure of DNA adducts [3] ...

PURPOSE To evaluate the effects of the dipeptide L-alanyl-glutamine (L-Ala-Gln) as a preconditioning agent to potentially promote reduction in the intensity of lesion or induction of resilience in rats subjected to global cerebral ischemia/reperfusion (I/R) injury. METHODS Thirty-six male Wistar rats weighing 280-300 g were randomly assigned to six groups (n = 6). Groups Sham 1h and 24h were ...

Introduction: With the increasing development of nanotechnology, nanomaterials are used instead of conventional compounds. One of these nanomaterials that have many applications in the biomedical field, is iron oxide (Fe2O3) nanoparticles and there is not much research on its effects on the physiological features. So in this research, effect of iron oxide nanoparticles on short and long-term...