in the present study, the effects of intracerebroventricular (icv) administration of normal saline (control), histamine, mepyramine (a histamine h1-receptor antagonist) and ranitidine (a histamine h2-receptor antagonist) were investigated on the formalin-induced pain in rabbits. subcutaneous (sc) injection of a formalin (100 μl, 5%) solution into the ventral surface of the right hind paw was pe...

  Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain.   Material and Methods: Two stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inf...

objective(s): the present study investigated the effects of microinjection of histamine and histamine h1, h2, and h3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (psc) on inflammatory pain.   material and methods: two stainless steel guide canulas were bilaterally implanted into the psc of anaesthetized rats. inflammator...

objective: to investigate the effect of intracerebroventricular injection of histamine on pain induced by subcutaneous iniection of formalin in the left ear of rabbit and the effect of the amine on morphine analgesia and naloxone hyperalgesia. design: experimental study. animals: sixty - six male new zealand white rabbits weighing 2.640.16kg. procedure: intracerebroventricular injections of the...

In the present study, the effects of intracerebroventricular (ICV) administration of normal saline (control), histamine, mepyramine (a histamine H1-receptor antagonist) and ranitidine (a histamine H2-receptor antagonist) were investigated on the formalin-induced pain in rabbits. Subcutaneous (SC) injection of a formalin (100 μl, 5%) solution into the ventral surface of the right hind paw was pe...

It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...

It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...