cognitive deficits such as impairments in attention, memory, information processing and executive functioning can be found in some parkinson's disease (pd) patients. recent studies suggested that pd drivers generally performed poorer than their healthy age-matched controls with regards to their cognitive and motor abilities during the psychometric testing. according to michon’s model of ca...

background: ionizing radiation causes cognitive impairment in adult brain. however, the effects of various irradiation protocols with fractionated fixed total dose on hippocampal function have not yet been studied. materials and methods: fractionated whole brain irradiation with a total dose of 36 gy was performed according to the following protocols: 2gy-18 fractions (2gy*18), 4gy-9 fraction (...

the serotonin (5-ht) receptors are a group of g protein-coupled receptors (gpcrs) and ligand-gated ion channels that found in the central and peripheral nervous systems. 5ht receptor can substantially influence brain functions such as learning and memory, perception of the environment, mood states, and responses to alcohol and other drugs of abuse. lysergic acid diethylamide (lsd) as a 5ht rece...

people with alzheimer disease (ad) have decreases in brain cell function that may increase their risks as drivers. the changes in brain cells affect memory (at first, short-term memory and then much later, long-term memory) and other thinking functions. in addition, people with early ad, though often very functional in many areas of life, may not be as competent behind the wheel of a car as tho...

Introduction: Cognitive dysfunction is the most common problem of patients with Alzheimer disease (AD). The pathological mechanism of cognitive impairment in AD may contribute to neuronal loss, synaptic dysfunction, and alteration in neurotransmitters receptors. Mitochondrial synapses dysfunction due to the accumulation of amyloid beta (Aβ) is one of the earliest pathological features of AD. Th...

the multiple sclerosis (ms) is a chronic disease of cns leads to some dysfunctions including cognitive (working memory), mood (depression) and fatigue. in spite of previous investigations about working memory impairment in patients with ms, there are scare evidences for working memory dysfunction in mild disabled ms patients (edss