Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated an...

In an era of discrete tube or transistor op-amp modules, any potential advantage to be gained from fully-differential circuitry was masked by primitive op-amp module performance. Fullydifferential output op-amps were abandoned in favor of single ended op-amps. Fully-differential op-amps were all but forgotten, even when IC technology was developed. The main reason appears to be the simplicity o...

Osteopontin (OP) is a multifunctional cytokine and adhesion protein that contains an RGD (argininglycin-aspartate) binding sequence that enables it to interact with several integrins, CD44 variants, and other adhesion receptors. OP receptor binding then directly or indirectly activates intracellular signaling pathways, mediating its effects on cell–matrix and cell–cell interactions. OP is incre...

Compared with normal littermates, the op/op mice had very few macrophages in the peritoneal cavity and severely reduced numbers of monocytes in the peripheral blood. Moreover, osteopetrotic animals demonstrated an altered distribution of hemopoietic tissue with a 10-fold decrease in the number of marrow cells. Liver hemopoiesis persisted in 4-wk-old mice as evidenced by the presence of hemopoie...

An original pathway to renewable production of phenol-rich bio-oil by fast pyrolysis pretreated olive pomace (OP) was researched. However, inherent inorganic elements (especially alkali and alkaline earth metals) in biomass feedstocks largely modified the final composition. To alter their catalytic activity pyrolysis, different demineralisation processes (water, acid pretreatments) were employe...