Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. In vitro and animal studies have linked neuroinflammation to Alzheimer's disease (AD) pathology. Studies on marke...

mers or ADDLs appear to accumulate in the AD brain. These soluble aggregates have been shown to be potent neurotoxins that can acutely disrupt neuronal func-In this issue of Neuron, a study by Billings et al. tion in vivo. The limited immunohistochemical studies points to intracellular A␤ as a possible cause of neu-using antibodies that recognize these oligomers or ronal dysfunction. In a mouse...

This article aims to show which extent the Arab and Muslim historians geographers are aware of familiar with Byzantine empire’s territories (Roman territories), their information about its administrative military divisions in first eight Hijri centuries (8-14 AD), is period Roman were under rule, later by Seljuk who dominated these after Battle Manzikert 463 AH / 1071 AD, before submission Otto...

This paper describes the historical evolution of Spanish causative micro-constructions with motion verbs llevar (‘take’) and traer (‘bring’) (e.g., el miedo llevó al ladrón a cometer un error, ‘the fear caused thief to make mistake’). In order reconstruct development these between 13th 20th centuries, all uses were extracted from Corpus del Diccionario Histórico. corpus was annotated for series...

Quarries represent ‘landscapes archives’ as they supplied the stone required for historical buildings. Among them, Caumont ancient quarry stands out in northern France, with its huge dimensions and role, providing building stones at a regional scale since least Middle Ages. The present study aims to approach quarrying methods used over time by means of an optimized methodological approach. desi...