Early life is a critical period for the development of solid organs and immune system. Regulatory T cells (Tregs) are present in skin during first week life, but their function neonatal unknown. We used Foxp3-DTR transgenic mice to assess importance Tregs. Histology, flow cytometry whole transcriptome was analyzed understand mechanisms Treg-mediated homeostasis. A peak expression Treg activatio...

Department of Chemistry, University of [email protected]; Fax: +44 114 222 9 Biomedical Research Centre, Sheffield Hall Departamento de Qúımica, QOPNA and S Universidade de Aveiro, 3810-193, Aveiro, P Departamento de Qúımica, CICECO and S Universidade de Aveiro, 3810-193, Aveiro, +351 234 370 084; Tel: +351 234 370 729 † Electronic supplementary information details, crystallographic data, ...

In a model with both issues of sovereign debtor moral hazard and creditor coordination under incomplete information, we show that the resulting con‡ict between ex ante and interim e¢ ciency limits the welfare impact of strengthening CACs. Conditional on default, we show that an interim e¢ cient CAC threshold exists and improving creditor coordination results in welfare gains. However, when ex a...

Opportunistic networking — forwarding messages in a disconnected mobile ad hoc network via any encountered nodes — offers a new mechanism for exploiting the mobile devices that many users now carry. Forwarding messages in such a network often involves the use of social-network routing— sending messages via nodes in the sender or recipient’s friends list. Simple social-network routing, however, ...

End-on view of the atomic model of the bacterial actinlike ParM protein double-helical fi lament, generated from an electron microscopic reconstruction. A bipolar spindle of antiparallel ParM fi laments pushes plasmids to the cell poles, constituting the simplest known apparatus for the segregation of genetic information. The loops on the outside of the 8to 9-nanometer-thick fi laments are invo...

Role of Cardiac Magnetic Resonance Imaging in the Assessment of Myocardial Viability Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000120294.67948.E3 2004;109:1328-1334 Circulation. http://circ.ahajournal...