نتایج جستجو برای: Cellular senescence
تعداد نتایج: 453587 فیلتر نتایج به سال:
Objective(s): Lipocalin2 (Lcn2) gene is highly expressed in response to various types of cellular stresses. The precise role of Lcn2 has not been fully understood yet. However, it plays a key role in controlling vital cellular processes such as proliferation, apoptosis and metabolism. Recently it was shown that Lcn2 decreases senescence and increases proliferation of mesenchymal stem cells (MSC...
Background: Aging is one of the important factors in the development of age-related diseases. Acrylamide can be produced during carbohydrate-rich foods prepared at high temperatures. Recently, studies showed that acrylamide can induce cellular senescence. On the other hand, Rutin as a natural flavonoid, has a potent antioxidant activity. Objective: This study aims to evaluate the ptotective ef...
objective(s): lipocalin2 (lcn2) gene is highly expressed in response to various types of cellular stresses. the precise role of lcn2 has not been fully understood yet. however, it plays a key role in controlling vital cellular processes such as proliferation, apoptosis and metabolism. recently it was shown that lcn2 decreases senescence and increases proliferation of mesenchymal stem cells (msc...
In order to find out the importance of flag leaf in Hordeum vulgare L. cv. Hordea in some physiologic traits and photosynthetic and leaf senescence-related gene expression, a field experiment was carried out in Warwick University Research Farm, UK, in 2003. For more accuracy and statistical comparison of the calculated means, the experiment was carried out in 4 replicates. Random leaf samples w...
Background: Chronic hyperglycemia is associated with an increase in cellular damage due to oxidative stress and increases insulin resistance and also increases in p53 and p16 beta cells, leading to the induction of senescence in pancreatic insulin-secreting cells. The aim of this study was the effect of eight weeks of aerobic exercise on the expression of senescence proteins P53 and P16 in the ...
Background and purpose: Induction of cellular senescence is indicative of new strategy to prevent abnormal proliferation of cancer cells. Doxorubicin (DOX) is gaining attention for its neoplasia suppressive and inhibitory properties, but its clinical utility is limited due to irreversible effects on non-target cells/tissues. In this way, nanoliposomal structures were developed in drug delivery ...
Cellular senescence, a state of permanent cell cycle arrest in response to endogenous and exogenous stimuli, triggers series gradual alterations structure, metabolism, function, as well inflammatory gene expression that nurtures low-grade proinflammatory milieu human tissue. A growing body evidence indicates an accumulation senescent neurons blood vessels stress aging the retina. Prolonged cell...
Objective(s): In this paper, we discussed natural agents with protective effects against stem cell senescence. Different complications have been observed due to stem cell senescence and the most important of them is “Aging”. Senescent cells have not normal function and their secretary inflammatory factors induce chronic inflammation in body which causes different patho...
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