Introduction: It has been reported that doxorubicin can cause liver damage; however, exercise and crocin consumption can improve antioxidant defense.The aim of the present study was to investigate the antioxidant effect of continuous training with crocin consumption on the liver tissue of doxorubicin-poisoned rats. Methods: In this experimental...

Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...

Malignant tumors of head and neck carcinomas are the sixth most common type of cancer. Current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. Consequently, there is much interest in identifying new drugs for cancer treatment. Crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. ...

objective: crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. the present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. materials and methods: local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hin...

Cervical cancer ranks third in incidence worldwide and is the most frequent gynecological developing countries. This study aimed to investigate effect of crocin on resistance HELA/Ara-C cells chemo-agent Ara-C. which was defined as Ara-C-resistant HELA cell line, were treated with crocin. After that, proliferation, apoptosis, cycle assay examined by MTT assay, AO/EB staining, flow cytometry, re...

In this study, the effect of crocin, a substance found in Crocus sativus L. stigmata on nervous system development and regeneration was investigated. Crocin is a glycosyl ester of the polyene dicarboxylic acid crocetin and is one of the few families of carotenoids found in nature, which are freely soluble in water. In the first experiment, the effect of crocin (30 microM, 60 microM and 120 micr...

objective(s): in this study, the effects of crocin against subchronic toxicity of diazinon (dzn) on systolic blood pressure (sbp) and heart rate (hr) were evaluated in rats. materials and methods: rats were equally divided into 7 groups; control (corn oil), dzn (15 mg/kg), crocin (each group received 12.5, 25 or 50 mg/kg crocin plus dzn), vitamin e (200 iu/kg plus dzn) and crocin (50 mg/kg) tre...

Neuropathic pain is caused by a lesion or disease affecting the nervous systems, and is generally manifested as spontaneous pain, hyperalgesia, and allodynia. Previous study indicate that saffron has anti-inflammatory and antioxidant properties, we investigated whether saffron and crocin, a major constitute of saffron, would infleuence on behavioral responses of pain induced by chronic constric...

Objective(s): The drinking of ethanol causes the wide range of clinical illness and morphological changes including hepatotoxicity and nephrotoxicity. In the current study, the protective properties of crocin versus oxidative stress, apoptosis and inflammation induced by ethanol were assessed. Materials and Methods: The male Wistar rats ...