Previous works by the authors [Wei et al., 2003; 2004] have developed a simple bearing-only control law for a mobile robot with demonstrated convergence to a unique final pose and orientation. Here, we use a time-varying weight strategy to first draw the robot towards a known “good” starting region and then a second set of weights is used for docking. This strategy allows the robot to dock succ...

This study addresses the pickup and delivery problem for cross-docking strategy, in which shipments are allowed to be transferred from suppliers to retailers directly as well as through cross-docks. Usual models that investigate vehicle routing in cross-docking networks force all vehicles to stop at the cross-dock even if a shipment is about to a full truckload or the vehicle collects and deliv...

In this study, to accommodate receptor flexibility, based on multiple receptor conformations, a novel ensemble docking protocol was developed by using the naïve Bayesian classification technique, and it was evaluated in terms of the prediction accuracy of docking-based virtual screening (VS) of three important targets in the kinase family: ALK, CDK2, and VEGFR2. First, for each target, the repr...

{ This paper presents a sensor based docking strategy for a non holonomic mobile platform used to support material transportation operations in industrial like environments. A low cost in-frared sensor system was designed and implemented, aiming at locating the mobile platform relative to the docking station where passive reeectors are installed. With this information, trajectories are generate...

A database of about 700 high-resolution kinase structures was used to test the reliability of 17 docking procedures (using six docking software packages) by means of self- and cross-docking studies. The analysis of about 80 000 docking calculations suggests that the docking of an unknown ligand into a kinase has a probability of only 30-37% to be a correct ligand pose. However, based on the hyp...

Background: Multidrug resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression/overactivation of ABC transporters, especially P-glycoprotein (P-gp), in the development of chemotherapy has long been demonstrated. Salinispora is a marine actinomycete genus known for the production of novel bioactive metabolites. Methods: In this...

In a supply chain, cross-docking is one of the most innovative systems for ameliorating the operational performance at distribution centers. Cross-docking is a logistics strategy in which freight is unloaded from inbound trucks and (almost) directly loaded into outbound trucks, with little or no storage in between, thus no inventory remains at the distribution center. In this study, we consider...

Developing chemicals that inhibit checkpoint kinase 1 (Chk1) is a promising adjuvant therapeutic to improve the efficacy and selectivity of DNA-targeting agents. Reliable prediction of binding-free energy and binding affinity of Chk1 inhibitors can provide a guide for rational drug design. In this study, multiple docking strategies and Prime/Molecular Mechanics Generalized Born Surface Area (Pr...

Prediction of the bound configuration of small-molecule ligands that differ substantially from the cognate ligand of a protein co-crystal structure is much more challenging than re-docking the cognate ligand. Success rates for cross-docking in the range of 20-30 % are common. We present an approach that uses structural information known prior to a particular cutoff-date to make predictions on l...